Skin - Nonmelanocytic tumors
Adnexal tumors - eccrine sweat glands
Syringoma / syringomatous carcinoma

Author: Christopher Hale, M.D. (see Authors page)

Revised: 6 October 2016, last major update June 2012

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Syringomatous carcinoma

Cite this page: Syringoma / syringomatous carcinoma. website. Accessed October 22nd, 2016.
Definition / General
  • Lower eyelids of women; also face and neck, vulva, dorsal proximal and middle phalanges of hand (Dermatoendocrinol 2009;1:282); also eruptive forms (below)
  • Four clinical variants - localized, familial, Down syndrome-associated, generalized (multiple and eruptive)
  • Appears to derive from sweat duct ridge

Eruptive syringoma
  • Neck, anterior trunk, axilla, shoulder, anterior surfaces of arms, abdomen or pubic areas of young men or women
  • May be reactive hyperplasia of eccrine glands, not neoplastic

Syringomatous carcinoma
  • Infiltrative epithelial tumors resembling syringomas
Case Reports
Eruptive syringoma
Syringomatous carcinoma
Clinical Images

Images hosted on other servers:

Disseminated brownish papules

Eruptive syringoma - Multiple flat papules on the thighs

Gross Description
  • Multiple, yellow, papulonodular lesions
Micro Description
  • Upper dermal clusters of small ducts lined by two layer thick epithelium, occasionally with comma shaped extensions
  • May have clear cells (due to glycogen)
  • Not infiltrative, no atypia, no mitotic figures, no local destruction

Syringomatous carcinoma
  • Tubules, keratinizing cystic structures, islands and cords within desmoplastic stroma
  • Involve epidermis and diffusely infiltrates dermis
Micro Images

Images hosted on PathOut server:

Courtesy of Angel Fernandez-Flores, M.D., Ph.D.

Images hosted on other servers:

Various images

Eruptive syringoma

Syringomatous carcinoma

Electron Microscopy Description
  • Eccrine origin
Differential Diagnosis
  • Basal cell carcinoma
  • Desmoplastic trichoepithelioma

Syringomatous carcinoma
  • Microcystic adnexal carcinoma
  • Syringoma: usually multiple, limited to upper dermis, not infiltrative, no atypia, no mitoses, no local destruction
  • Syringomatous carcinoma of salivary glands: in oral mucosa not skin
Additional References