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Skin - Nonmelanocytic tumors

Adnexal tumors - eccrine sweat glands

Syringoma / syringomatous carcinoma

Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 4 July 2012, last major update June 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
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● Lower eyelids of women; also face and neck, vulva, dorsal proximal and middle phalanges of hand (Dermatoendocrinol 2009;1:282); also eruptive forms (below)
● Four clinical variants - localized, familial, Down syndrome-associated, generalized (multiple and eruptive)
● Appears to derive from sweat duct ridge

Gross description
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● Multiple, yellow, papulonodular lesions

Clinical images
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Disseminated brownish papules

Syringoma: common skin lesions

Micro description
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● Upper dermal clusters of small ducts lined by two layer thick epithelium, occasionally with comma shaped extensions
● May have clear cells (due to glycogen)
● Not infiltrative, no atypia, no mitotic figures, no local destruction

Micro images
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Contributed by Angel Fernandez-Flores, MD, PhD, Hospital El Bierzo and Clinica Ponferrada, Spain

       

       
Various images

Electron microscopy description
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● Eccrine origin

Differential diagnosis
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● Desmoplastic trichoepithelioma
● Basal cell carcinoma

Eruptive syringoma

General
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● Neck, anterior trunk, axilla, shoulder, anterior surfaces of arms, abdomen or pubic areas of young men or women
● May be reactive hyperplasia of eccrine glands, not neoplastic

Case reports
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● 28 year old woman (Indian J Dermatol 2009;54:65)

Clinical images
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Multiple flat papules on the thighs

Micro images
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Various images

Syringomatous carcinoma

General
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● Infiltrative epithelial tumors resembling syringomas

Case reports
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● 50 year old woman, 83 year-old woman, and 54 year-old man with periorbital lesions (Br J Ophthalmol 1997;81:668)

Micro description
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● Tubules, keratinizing cystic structures, islands and cords within desmoplastic stroma
● Involve epidermis and diffusely infiltrates dermis

Micro images
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Differential diagnosis
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● Microcystic adnexal carcinoma
● Syringoma: usually multiple, limited to upper dermis, not infiltrative, no atypia, no mitoses, no local destruction
● Syringomatous carcinoma of salivary glands: in oral mucosa not skin

End of Skin - Nonmelanocytic tumors > Adnexal tumors - eccrine sweat glands > Syringoma / syringomatous carcinoma

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