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Skin - Nonmelanocytic tumors

Carcinoma (non-adnexal)

Verrucous carcinoma

Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 15 July 2012, last major update June 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
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● Also known as epithelioma cuniculatum
● Usually mucosal sites such as oral cavity, glans penis, vulva, cervix
● Non mucosal skin is rare - usually sole of foot with frequent extension to bone
● Nodal metastases are rare

Case reports
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● 55 year old man with growth on right heel (Dermatol Online J 2006;12:8)

Clinical images
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Various images

Gross description
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● Ulcerating, fungating or polypoid mass with sinus tracts opening onto skin surface

Micro description
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● Very well differentiated, ulcerating, fungating mass with deep sinus tracts
● Composed of lobules of mature squamous epithelium with minimal atypia
● Tumor lobules may invade and destroy bone
● Few mitotic figures, variable stromal response

Micro images
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Various images

Positive stains
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● HPV (frequently, usually 16, 6, 11)

Differential diagnosis
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● Cysts
● Benign keratoses

End of Skin - Nonmelanocytic tumors > Carcinoma (non-adnexal) > Verrucous carcinoma

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