Skin - Nonmelanocytic tumors
Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 28 April 2014, last major update June 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.
● Also known as epithelioma cuniculatum
● Usually mucosal sites such as oral cavity, glans penis, vulva, cervix
● Non mucosal skin is rare - usually sole of foot with frequent extension to bone
● Nodal metastases are rare
● 55 year old man with growth on right heel
(Dermatol Online J 2006;12:8)
● Ulcerating, fungating or polypoid mass with sinus tracts opening onto skin surface
● Very well differentiated, ulcerating, fungating mass with deep sinus tracts
● Composed of lobules of mature squamous epithelium with minimal atypia
● Tumor lobules may invade and destroy bone
● Few mitotic figures, variable stromal response
Contributed by Dr. Asmaa Gaber Abdou, Menoufiya University (Egypt)
● HPV (frequently, usually 16, 6, 11)
● Benign keratoses
End of Skin - Nonmelanocytic tumors > Carcinoma (non-adnexal) > Verrucous carcinoma
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