Skin tumor - Nonmelanocytic - Woringer-Kolopp disease

Home Chapter Home Jobs Conferences Fellowships Books

Skin - Nonmelanocytic tumors

Lymphoma and related disorders

Woringer-Kolopp disease

Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 15 July 2012, last major update July 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
=========================================================================

● Also called pagetoid reticulosis
● Indolent, T cell cutaneous proliferative disorder related to mycosis fungoides
● 2:1 male to female incidence
● Usually solitary lesion on distal extremities
● Disseminated lesions called Ketron-Goodman disease

Treatment
=========================================================================

● May include electron beam, pharmacological intervention, psoralen plus ultraviolet A (PUVA) photochemotherapy, radiotherapy, or surgery (J Clin Aesthet Dermatol 2010;3:46)

Case reports
=========================================================================

● 24 year old woman with slowly enlarging plaque (J Clin Aesthet Dermatol 2010;3:46)
● 84 year old man with 2 year history of erythematous patches (Case Rep Dermatol 2009;1:39)

Gross description
=========================================================================

● Solitary erythematosquamous patch

Gross images
=========================================================================

Distant (a) and closer (b) views of pagetoid reticulosis presenting as a 10x10mm plaque on the medial side of distal right foot

Micro description
=========================================================================

● Monomorphic intraepidermal infiltrate of mycosis fungoides-like cells, in Paget’s disease type pattern

Micro images
=========================================================================

Psoriasiform hyperplasia of the epidermis with acanthosis and overlying hyperkeratosis and parakeratosis

Immunostains

Positive stains
=========================================================================

● Either CD4+ CD8+ or CD4- CD8-

Differential diagnosis
=========================================================================

● Mycosis fungoides

End of Skin - Nonmelanocytic tumors > Lymphoma and related disorders > Woringer-Kolopp disease

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).