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Skin - Nonmelanocytic tumors

Lymphoma and related disorders

Woringer-Kolopp disease


Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 15 July 2012, last major update July 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
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● Also called pagetoid reticulosis
● Indolent, T cell cutaneous proliferative disorder related to mycosis fungoides
● 2:1 male to female incidence
● Usually solitary lesion on distal extremities
● Disseminated lesions called Ketron-Goodman disease

Treatment
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● May include electron beam, pharmacological intervention, psoralen plus ultraviolet A (PUVA) photochemotherapy, radiotherapy, or surgery (J Clin Aesthet Dermatol 2010;3:46)

Case reports
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● 24 year old woman with slowly enlarging plaque (J Clin Aesthet Dermatol 2010;3:46)
● 84 year old man with 2 year history of erythematous patches (Case Rep Dermatol 2009;1:39)

Gross description
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● Solitary erythematosquamous patch

Gross images
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Distant (a) and closer (b) views of pagetoid reticulosis presenting as a 10x10mm plaque on the medial side of distal right foot

Micro description
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● Monomorphic intraepidermal infiltrate of mycosis fungoides-like cells, in Pagetís disease type pattern

Micro images
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Psoriasiform hyperplasia of the epidermis with acanthosis and overlying hyperkeratosis and parakeratosis

   
Immunostains

Positive stains
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● Either CD4+ CD8+ or CD4- CD8-

Differential diagnosis
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● Mycosis fungoides

End of Skin - Nonmelanocytic tumors > Lymphoma and related disorders > Woringer-Kolopp disease


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