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Small bowel (small intestine)

Infectious disorders

CMV


Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 17 December 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● CMV infections associated with immunosuppression, HIV; usually reflects disseminated infection if present in gut
● May cause necrotizing injury and perforation
● CMV duodenitis may present with bleeding or ulceration

Micro description
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● Inclusions in endothelial cells, fibroblasts, smooth muscle cells
● Necrosis and granulation tissue associated with moderate/marked lymphoplasmacytic infiltrate (Scand J Gastroenterol 2011;46:1228 )
● Small bowel allografts: circumscribed area of mucosal injury with few eosinophils (Transplant Proc 2010;42:2671)

Micro images
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Various images




38 year old man with CMV pouchitis, post-surgery for ulcerative colitis; note nucleomegaly with intranuclear inclusions (courtesy of Dr. Hanni Gulwani)

Additional references
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Endoscopy 2007;39:E23, J Clin Pathol 2006;59:1133

End of Small bowel (small intestine) > Infectious disorders > CMV


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