Small bowel (small intestine) - Gastrointestinal autonomic tumor (GANT)

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Small bowel (small intestine)

Other malignancies

Gastrointestinal autonomic tumor (GANT)

Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 22 December 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Variant of gastrointestinal stromal tumors with ultrastructural neural differentiation (Am J Surg Pathol 2001;25:979)
● Requires EM for diagnosis
● Mean age 55 years, usually men
● Usually small bowel, mesentery, retroperitoneum
● Usually malignant

Case reports
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63 year old woman (Chirurg 2001;72:600)

Gross description
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● >10 cm, well circumscribed, transmural involvement of bowel wall
● Tan-pink, lobulated, hemorrhagic with necrosis and cystic degeneration

Micro description
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● Interlacing spindle cells with minimal pleomorphism, skenoid fibers and myxoid change, 1-2 mitoses/10 HPF

Positive stains
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● CD117, CD34 (variable), vimentin, NSE

Negative stains
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● Muscle markers

Electron microscopy description
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● Neuron like cells with axonal cytoplasmic processes
● Synapse like structures
● Dense core neurosecretory granules

Electron microscopy images
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Various images

End of Small bowel (small intestine) > Other malignancies > Gastrointestinal autonomic tumor (GANT)

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