Small bowel (small intestine)
Other malignancies
Gastrointestinal autonomic tumor (GANT)

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 23 February 2018, last major update August 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Gastrointestinal autonomic tumor small bowel

Cite this page: Gulwani, H. Gastrointestinal autonomic tumor (GANT). website. Accessed October 19th, 2018.
Definition / general
  • Variant of gastrointestinal stromal tumors with ultrastructural neural differentiation (Am J Surg Pathol 2001;25:979)
  • Requires EM for diagnosis
  • Mean age 55 years, usually men
  • Usually small bowel, mesentery, retroperitoneum
  • Usually malignant
Case reports
Gross description
  • > 10 cm, well circumscribed, transmural involvement of bowel wall
  • Tan pink, lobulated, hemorrhagic with necrosis and cystic degeneration
Microscopic (histologic) description
  • Interlacing spindle cells with minimal pleomorphism, skenoid fibers and myxoid change, 1 - 2 mitoses/10 HPF
Positive stains
Negative stains
  • Muscle markers
Electron microscopy description
  • Neuron-like cells with axonal cytoplasmic processes
  • Synapse-like structures
  • Dense core neurosecretory granules
Electron microscopy images

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Various images