Small bowel (small intestine)
Inflammatory disorders
Graft versus host disease


Topic Completed: 1 August 2012

Revised: 12 March 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Graft versus host disease[TI] small bowel[TIAB]

Hanni Gulwani, M.B.B.S.
Page views in 2018: 334
Page views in 2019 to date: 257
Cite this page: Gulwani H. Graft versus host disease. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/smallbowelGVHD.html. Accessed July 19th, 2019.
Definition / general
  • Apoptotic cells and fibrosis commonly associated with allogeneic bone marrow transplant (Dig Dis Sci 2012;57:720)
  • Recommended to delay biopsies until week 4 of immunosuppressive therapy or later
  • Symptoms include severe watery diarrhea, changes in skin and liver
Case reports
Gross images

Images hosted on other servers:

Severe chronic GVHD
involving small intestine,
leading to obstruction
of terminal ileum

Microscopic (histologic) description
  • Acute: epithelial crypt apoptosis with minimal inflammation; severe cases have sloughing of mucosa
  • Chronic: lamina propria fibrosis and submucosal fibrosis extending up to serosa
Microscopic (histologic) images

Images hosted on other servers:

Severe loss of mucosal epithelium, many basal single cell apoptotic bodies, crypt dropout, submucosal / subserosal fibrosis

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