Small bowel (small intestine)
Inflammatory disorders
Graft versus host disease

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 13 February 2018, last major update August 2012

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Graft versus host disease[TI] small bowel[TIAB]

Cite this page: Gulwani, H. Graft versus host disease. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/smallbowelGVHD.html. Accessed February 25th, 2018.
Definition / general
  • Apoptotic cells and fibrosis commonly associated with allogeneic bone marrow transplant (Dig Dis Sci 2012;57:720)
  • Recommended to delay biopsies until week 4 of immunosuppressive therapy or later
  • Symptoms include severe watery diarrhea, changes in skin and liver
Case reports
Gross images

Images hosted on other servers:

Severe chronic GVHD
involving small intestine,
leading to obstruction
of terminal ileum

Microscopic (histologic) description
  • Acute: epithelial crypt apoptosis with minimal inflammation; severe cases have sloughing of mucosa
  • Chronic: lamina propria fibrosis and submucosal fibrosis extending up to serosa
Microscopic (histologic) images

Images hosted on other servers:

Severe loss of mucosal epithelium, many basal single cell apoptotic bodies, crypt dropout, submucosal / subserosal fibrosis