Small bowel (small intestine) - Hodgkin’s lymphoma

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Small bowel (small intestine)

Lymphoma

Hodgkin’s lymphoma

Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 20 December 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Stringent criteria suggested due to rarity of primary disease and possible confusion with secondary spread
● Associated with inflammatory bowel disease or longstanding chronic inflammation, combined with chronic immunosuppression; in these cases, may be due to Epstein-Barr virus associated lymphoproliferation (Am J Surg Pathol 2000;24:66)

Case reports
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● 38 year old man with Crohn's disease for 24 years (Arch Pathol Lab Med 2001;125:424)
● 79 year old man with low grade fever (J Cancer Res Ther 2010;6:342)

Treatment
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● Discontinuation of immunosuppressive therapy may be helpful

Gross description
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● Transmural involvement of bowel wall, often multifocal, associated with fissuring ulcers, diverticula with abscesses

Micro description
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● Reed-Sternberg cells in background of lymphoid hyperplasia, occasional granulomas

Micro images
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Various images

Positive stains
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● CD15, CD30

Negative stains
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● CD45 (LCA)

End of Small bowel (small intestine) > Lymphoma > Hodgkin’s lymphoma

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