Cite this page: Gulwani H. Neurofibroma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/smallbowelNF.html. Accessed November 11th, 2019.
Definition / general
- Associated with multiple endocrine adenomatosis or von Recklinghausen disease (neurofibromatosis 1)
- With NF1, also associated with hyperplasia of submucosal and myenteric nerve plexuses, mucosal ganglioneuromatosis, GI stromal tumors, gangliocytic paraganglioma
- GISTs arising in NF1 do not express the typical sporadic GIST mutations of KIT exon 9, 11, 13 or 17 or PDGFRA exon 12 or 18; suggesting a different pathogenesis (Am J Surg Pathol 2006;30:90)