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Small bowel (small intestine)

Other malignancies

Zollinger-Ellison syndrome


Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 12 December 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Syndrome due to production of gastrin that enters systemic circulation by gastric, pancreatic or peripancreatic carcinoids
● Tumors may be very small and difficult to detect

Micro description
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● Variable villus abnormality with increased chronic inflammatory cells and neutrophils in lamina propria; may have surface erosions
● Also gastric foveolar metaplasia of duodenum
● May be normal by H & E but abnormal by EM

End of Small bowel (small intestine) > Other malignancies > Zollinger-Ellison syndrome


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