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Small bowel (small intestine)
Other malignancies
Zollinger-Ellison syndrome


Topic Completed: 1 August 2012

Revised: 15 March 2019

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PubMed Search: Zollinger-Ellison syndrome[TIAB] small bowel
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Table of Contents
Definition / general | Microscopic (histologic) description
Cite this page: Gulwani H. Zollinger-Ellison syndrome. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/smallbowelZEsyndrome.html. Accessed April 24th, 2019.
Definition / general
  • Syndrome due to production of gastrin that enters systemic circulation by gastric, pancreatic or peripancreatic carcinoids
  • Tumors may be very small and difficult to detect
Microscopic (histologic) description
  • Variable villus abnormality with increased chronic inflammatory cells and neutrophils in lamina propria; may have surface erosions
  • Also gastric foveolar metaplasia of duodenum
  • May be normal by H&E but abnormal by EM
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