Small bowel (small intestine)
Other malignancies
Zollinger-Ellison syndrome

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 23 February 2018, last major update August 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Zollinger-Ellison syndrome[TIAB] small bowel

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Cite this page: Gulwani, H. Zollinger-Ellison syndrome. website. Accessed January 23rd, 2019.
Definition / general
  • Syndrome due to production of gastrin that enters systemic circulation by gastric, pancreatic or peripancreatic carcinoids
  • Tumors may be very small and difficult to detect
Microscopic (histologic) description
  • Variable villus abnormality with increased chronic inflammatory cells and neutrophils in lamina propria; may have surface erosions
  • Also gastric foveolar metaplasia of duodenum
  • May be normal by H&E but abnormal by EM