Zollinger-Ellison syndrome

Small bowel (small intestine)
Other malignancies
Zollinger-Ellison syndrome

Author: Hanni Gulwani, M.B.B.S.

Topic Completed: 1 August 2012

Revised: 15 March 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Zollinger-Ellison syndrome[TIAB] small bowel

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Table of Contents

Definition / general | Microscopic (histologic) description

Cite this page: Gulwani H. Zollinger-Ellison syndrome. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/smallbowelZEsyndrome.html. Accessed June 17th, 2019.

Definition / general

Syndrome due to production of gastrin that enters systemic circulation by gastric, pancreatic or peripancreatic carcinoids
Tumors may be very small and difficult to detect

Microscopic (histologic) description

Variable villus abnormality with increased chronic inflammatory cells and neutrophils in lamina propria; may have surface erosions
Also gastric foveolar metaplasia of duodenum
May be normal by H&E but abnormal by EM