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Small bowel (small intestine)

Malabsorption

Acrodermatitis enteropathica


Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 14 December 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Autosomal recessive, linked to zinc deficiency, affects children
● Genetic defect mapped to SLC39A4 gene at 8q24, encodes zinc transporter Zip4 (J Am Acad Dermatol 2007;56:116)
● Cutaneous lesions (perioral and extremity skin lesions, alopecia, nail dystrophy), diarrhea, malabsorption

Treatment
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● Zinc sulfate

Micro description
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● Severe villus abnormality in some; normal in others

Electron microscopy description
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● Rodlike fibrillar inclusions in Paneth cells

End of Small bowel (small intestine) > Malabsorption > Acrodermatitis enteropathica


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