Table of Contents
Definition / general | Case reports | Gross description | Gross images | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Negative stains | Electron microscopy description | Additional referencesCite this page: Gulwani, H. Adenocarcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/smallboweladenocarcinoma.html. Accessed April 21st, 2018.
Definition / general
- Much less common in small intestine than in colon
- Men or women, ages 40 - 70, any site in small bowel
- Also associated with Lynch syndrome (hereditary nonpolyposis colorectal cancer), Crohn's disease, Peutz-Jeghers syndrome, von Recklinghausen disease, cholecystectomy, cystic fibrosis, Meckel diverticulum (Hum Pathol 2010;41:1087)
- May cause obstruction
- Usually advanced stage at diagnosis with deep wall penetration, nodal metastases
- Nodal metastases and distal location (jejunum and ileum) of tumor are most important independent prognostic factors (Hum Pathol 2010;41:1087)
- Presence of adenomatous component may be favorable prognostic factor
Case reports
- 36 year old woman, also with intestinal duplication of ileum (Rev Med Chil 2009;137:1341)
- 48 year old man, also with Crohn's disease (World J Gastroenterol 2009;15:1774)
- 64 year old woman with synchronous adenocarcinoma and carcinoid tumor of the terminal ileum (BMC Cancer 2005;5:157)
- 68 year old woman with ileal adenocarcinoma arising from multifocal gastric heterotopias (Med Oncol 2011;28:1023)
- 72 year old Japanese man with intramucosal adenocarcinoma of the ileum after ileosigmoidostomy (World J Surg Oncol 2009;7:41)
- Small bowel carcinoma mimicking relapse of Crohn's disease (J Crohns Colitis 2011;5:152)
Gross description
- Papillary or polypoid, may have napkin ring appearance (encircles lumen), proximal bowel dilation
Microscopic (histologic) description
- Often moderately well differentiated, mucin producing
- Scattered endocrine cells
Positive stains
Electron microscopy description
- Prominent microvilli