Adenocarcinoma

Duodenum: negative for CK20
Jejunum / ileum: negative for MUC1

Small bowel (small intestine)
Carcinoma
Adenocarcinoma

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 21 February 2018, last major update August 2012

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Adenocarcinoma[TI] small bowel[TI] free full text[sb]

See also: Ampullary adenocarcinoma

Table of Contents

Cite this page: Gulwani, H. Adenocarcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/smallboweladenocarcinoma.html. Accessed April 21st, 2018.

Definition / general

Much less common in small intestine than in colon
Men or women, ages 40 - 70, any site in small bowel
Also associated with Lynch syndrome (hereditary nonpolyposis colorectal cancer), Crohn's disease, Peutz-Jeghers syndrome, von Recklinghausen disease, cholecystectomy, cystic fibrosis, Meckel diverticulum (Hum Pathol 2010;41:1087)
May cause obstruction
Usually advanced stage at diagnosis with deep wall penetration, nodal metastases
Nodal metastases and distal location (jejunum and ileum) of tumor are most important independent prognostic factors (Hum Pathol 2010;41:1087)
Presence of adenomatous component may be favorable prognostic factor

Case reports

36 year old woman, also with intestinal duplication of ileum (Rev Med Chil 2009;137:1341)
48 year old man, also with Crohn's disease (World J Gastroenterol 2009;15:1774)
64 year old woman with synchronous adenocarcinoma and carcinoid tumor of the terminal ileum (BMC Cancer 2005;5:157)
68 year old woman with ileal adenocarcinoma arising from multifocal gastric heterotopias (Med Oncol 2011;28:1023)
72 year old Japanese man with intramucosal adenocarcinoma of the ileum after ileosigmoidostomy (World J Surg Oncol 2009;7:41)
Small bowel carcinoma mimicking relapse of Crohn's disease (J Crohns Colitis 2011;5:152)

Gross description