Small bowel (small intestine)
Carcinoma
Adenocarcinoma

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 21 February 2018, last major update August 2012

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Adenocarcinoma[TI] small bowel[TI] free full text[sb]

See also: Ampullary adenocarcinoma
Cite this page: Gulwani, H. Adenocarcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/smallboweladenocarcinoma.html. Accessed July 18th, 2018.
Definition / general
  • Much less common in small intestine than in colon
  • Men or women, ages 40 - 70, any site in small bowel
  • Also associated with Lynch syndrome (hereditary nonpolyposis colorectal cancer), Crohn's disease, Peutz-Jeghers syndrome, von Recklinghausen disease, cholecystectomy, cystic fibrosis, Meckel diverticulum (Hum Pathol 2010;41:1087)
  • May cause obstruction
  • Usually advanced stage at diagnosis with deep wall penetration, nodal metastases
  • Nodal metastases and distal location (jejunum and ileum) of tumor are most important independent prognostic factors (Hum Pathol 2010;41:1087)
  • Presence of adenomatous component may be favorable prognostic factor
Case reports
Gross description
  • Papillary or polypoid, may have napkin ring appearance (encircles lumen), proximal bowel dilation
Gross images

Images hosted on other servers:

Various images

Microscopic (histologic) description
  • Often moderately well differentiated, mucin producing
  • Scattered endocrine cells
Microscopic (histologic) images

Images hosted on other servers:

Various images

Positive stains
Negative stains
  • Duodenum: negative for CK20
  • Jejunum / ileum: negative for MUC1
Electron microscopy description
  • Prominent microvilli