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Small bowel (small intestine)

Lymphoma

Burkitt’s lymphoma


Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 22 December 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● High grade lymphoma, usually in children
● Endemic cases in Africa usually do not present with GI involvement
● Sporadic cases in Western world and Middle East may present with ileocecal involvement, pain or obstruction

Case reports
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● 16 year old boy with acute abdomen (Cases J 2009;2:9322)
● 24 year old man with Burkitt's lymphoma of ileum and renal cell carcinoma.(Can J Surg 2008;51:E77)

Gross images
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Ileocecal valve tumor contributed by Dr. Kaveh Naemi, Irvine, California


Terminal ileum tumor

Micro description
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● Small, noncleaved, monomorphic cells with round nuclei, prominent multiple nucleoli, basophilic cytoplasm
● Vacuoles on touch prep
● Starry sky appearance on low power

Micro images
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Ileocecal valve tumor (courtesy of Dr. Kaveh Naemi, Irvine, California)


Above ileocecal valve tumor (left to right): CD20+, CD10+, Ki-67 strong, bcl2- (contributed by Dr. Kaveh Naemi, Irvine, California)


Terminal ileum tumor (left to right): H&E, CD10+, Ki-67 (strong)

Cytology images
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Touch prep

Positive stains
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● CD20, CD10

Negative stains
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● CD5, CD23

Molecular description
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● c-myc translocations of t(8;14) and others

Molecular images
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Terminal ileum tumor: c-myc by FISH

End of Small bowel (small intestine) > Lymphoma > Burkitt’s lymphoma


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