Small bowel (small intestine) - Chronic idiopathic intestinal pseudo-obstruction

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Small bowel (small intestine)

Obstruction

Chronic idiopathic intestinal pseudo-obstruction

Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 18 December 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Symptoms of intestinal obstruction without mechanical obstruction
● Attributed to abnormal physiology of gut propulsive system

Etiology
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● Local manifestation of generalized disease: diabetes, hypoparathyroidism, Parkinson’s disease, SLE
● Diseases with intestinal pathology: amyloidosis, Chagas’ disease, dermatomyositis/polymyositis, Duchene’s muscular dystrophy, myotonic dystrophy, myxedema, scleroderma
● Also drugs (anti-Parkinson, clonidine, mushroom poisoning), pheochromocytoma, psychosis,
● May be due to marked reduction in interstitial cells of Cajal (Am J Surg Pathol 2003;27:228)
● By definition, excludes known mechanical causes of obstruction: cathartic colon, ceroidosis, Hirschsprung’s disease, visceral myopathies (muscle cell degeneration/loss, fibrosis of muscularis propria), visceral neuropathies (familial-Am J Surg Pathol 2010;34:1528, sporadic; require special techniques to demonstrate)

End of Small bowel (small intestine) > Obstruction > Chronic idiopathic intestinal pseudo-obstruction

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