Small bowel (small intestine)
Obstruction
Chronic idiopathic intestinal pseudo-obstruction

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 15 February 2018, last major update August 2012

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Chronic idiopathic intestinal pseudo-obstruction[TIAB]

Table of Contents
Definition / general | Etiology
Cite this page: Gulwani, H. Chronic idiopathic intestinal pseudo-obstruction. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/smallbowelchronicidiopathic.html. Accessed June 18th, 2018.
Definition / general
  • Symptoms of intestinal obstruction without mechanical obstruction
  • Attributed to abnormal physiology of gut propulsive system
Etiology
  • Local manifestation of generalized disease: diabetes, hypoparathyroidism, Parkinson disease, SLE
  • Diseases with intestinal pathology: amyloidosis, Chagas disease, dermatomyositis / polymyositis, Duchenne muscular dystrophy, myotonic dystrophy, myxedema, scleroderma
  • Also drugs (anti-Parkinson, clonidine, mushroom poisoning), pheochromocytoma, psychosis
  • May be due to marked reduction in interstitial cells of Cajal (Am J Surg Pathol 2003;27:228)
  • By definition, excludes known mechanical causes of obstruction: cathartic colon, ceroidosis, Hirschsprung disease, visceral myopathies (muscle cell degeneration / loss, fibrosis of muscularis propria), visceral neuropathies (familial - Am J Surg Pathol 2010;34:1528, sporadic; require special techniques to demonstrate)