Small bowel (small intestine)
Benign tumors and tumor-like conditions
Colchicine toxicity

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 16 February 2018, last major update August 2012

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Colchicine toxicity small bowel

Cite this page: Gulwani, H. Colchicine toxicity. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/smallbowelcolchicine.html. Accessed July 22nd, 2018.
Definition / general
  • Colchicine is an alkaloid with antimitotic ability used to treat various medical conditions; toxicity can result in multiorgan failure and death (Am J Surg Pathol 2001;25:1067)
Microscopic (histologic) description
  • Abundant epithelial mitotic figures with metaphase arrest
  • Often enlarged epithelial cells with condensed chromatin in a ring formation within center of cell
  • Associated with epithelial loss of polarity and pseudostratification
  • Nuclei small, hyperchromatic and compressed to periphery of cell