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Small bowel (small intestine)

Benign tumors and tumor-like conditions

Colchicine toxicity


Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 19 December 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Colchicine is an alkaloid with antimitotic ability used to treat various medical conditions; toxicity can result in multiorgan failure and death (Am J Surg Pathol 2001;25:1067)

Micro description
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● Abundant epithelial mitotic figures with metaphase arrest
● Often enlarged epithelial cells with condensed chromatin in a ring formation within center of cell
● Associated with epithelial loss of polarity and pseudostratification
● Nuclei small, hyperchromatic and compressed to periphery of cell

End of Small bowel (small intestine) > Benign tumors and tumor-like conditions > Colchicine toxicity


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