Small bowel (small intestine)
Benign tumors and tumor-like conditions
Colchicine toxicity


Topic Completed: 1 August 2012

Revised: 13 March 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Colchicine toxicity small bowel

Hanni Gulwani, M.B.B.S.
Page views in 2018: 42
Page views in 2019 to date: 71
Cite this page: Gulwani H. Colchicine toxicity. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/smallbowelcolchicine.html. Accessed November 20th, 2019.
Definition / general
  • Colchicine is an alkaloid with antimitotic ability used to treat various medical conditions; toxicity can result in multiorgan failure and death (Am J Surg Pathol 2001;25:1067)
Microscopic (histologic) description
  • Abundant epithelial mitotic figures with metaphase arrest
  • Often enlarged epithelial cells with condensed chromatin in a ring formation within center of cell
  • Associated with epithelial loss of polarity and pseudostratification
  • Nuclei small, hyperchromatic and compressed to periphery of cell
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