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Small bowel (small intestine)

Inflammatory disorders

Collagenous enterocolitis

Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 15 December 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.


● May be associated with collagenous colitis, collagenous gastritis or collagenous sprue
● High intraepithelial lymphocyte count in terminal ileum biopsies of affected patients (Mod Pathol 2003;16:115, Am J Surg Pathol 2002;26:1484, Am J Surg Pathol 2011;35:1151)
● Lymphocytes are mostly suppressor T cells
Symptoms: chronic nonbloody diarrhea, relatively normal endoscopy

Micro description

● Subepithelial collagen deposition in terminal ileum, partial villous atrophy

Micro images

Terminal ileum with increase in subepithelial collagen

Positive stains

● Trichrome highlights collagen

End of Small bowel (small intestine) > Inflammatory disorders > Collagenous enterocolitis

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