Small bowel (small intestine)
Benign tumors and tumor-like conditions
Cowden syndrome

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 16 February 2018, last major update August 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Cowden syndrome small bowel

Cite this page: Gulwani, H. Cowden syndrome. website. Accessed October 16th, 2018.
Definition / general
  • Autosomal dominant disorder with facial tricholemmomas, acral keratosis, oral mucosal papillomas, small intestinal and colorectal polyps
  • Also called multiple hamartoma syndrome
  • Increased risk of malignancy (breast and thyroid cancer) but not in polyps
  • Polyps have same histology as mucosal prolapse syndromes (colitis cystica profunda)
Microscopic (histologic) description
  • Hamartomatous features with disorganization and proliferation of muscularis mucosa
Microscopic (histologic) images

Images hosted on other servers:

Colorectal tumors: glands in lobular groupings embedded with relatively dense fibrous stroma

Differential diagnosis