Small bowel (small intestine)
Benign tumors and tumor-like conditions
Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 19 December 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.
● Autosomal dominant disorder with facial tricholemmomas, acral keratosis, oral mucosal papillomas, small intestinal and colorectal polyps
● Also called multiple hamartoma syndrome
● Increased risk of malignancy (breast and thyroid cancer), but not in polyps
● Polyps have same histology as mucosal prolapse syndromes (colitis cystica profunda)
● Hamartomatous features with disorganization and proliferation of muscularis mucosa
Colorectal tumors: glands in lobular groupings embedded with relatively dense fibrous stroma
● Peutz-Jeghers polyp
End of Small bowel (small intestine) > Benign tumors and tumor-like conditions > Cowden's syndrome
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