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Small bowel (small intestine)

Benign tumors and tumor-like conditions

Cowden's syndrome


Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 19 December 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Autosomal dominant disorder with facial tricholemmomas, acral keratosis, oral mucosal papillomas, small intestinal and colorectal polyps
● Also called multiple hamartoma syndrome
● Increased risk of malignancy (breast and thyroid cancer), but not in polyps
● Polyps have same histology as mucosal prolapse syndromes (colitis cystica profunda)

Micro description
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● Hamartomatous features with disorganization and proliferation of muscularis mucosa

Micro images
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Colorectal tumors: glands in lobular groupings embedded with relatively dense fibrous stroma

Differential diagnosis
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Peutz-Jeghers polyp

End of Small bowel (small intestine) > Benign tumors and tumor-like conditions > Cowden's syndrome


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