Small bowel (small intestine)
Benign tumors and tumor-like conditions
Cowden syndrome

Topic Completed: 1 August 2012

Revised: 13 March 2019

Copyright: 2003-2019,, Inc.

PubMed Search: Cowden syndrome small bowel

Hanni Gulwani, M.B.B.S.
Page views in 2019: 290
Page views in 2020 to date: 31
Cite this page: Gulwani H. Cowden syndrome. website. Accessed February 18th, 2020.
Definition / general
  • Autosomal dominant disorder with facial tricholemmomas, acral keratosis, oral mucosal papillomas, small intestinal and colorectal polyps
  • Also called multiple hamartoma syndrome
  • Increased risk of malignancy (breast and thyroid cancer) but not in polyps
  • Polyps have same histology as mucosal prolapse syndromes (colitis cystica profunda)
Microscopic (histologic) description
  • Hamartomatous features with disorganization and proliferation of muscularis mucosa
Microscopic (histologic) images

Images hosted on other servers:

Colorectal tumors: glands in lobular groupings embedded with relatively dense fibrous stroma

Differential diagnosis
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