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Small bowel (small intestine)

Benign tumors and tumor-like conditions

Cronkhite-Canada syndrome


Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 19 December 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Noninherited condition associated with high morbidity, characterized by GI hamartomatous polyposis, alopecia, onychodystrophy, hyperpigmentation, diarrhea (Dig Dis Sci 2012;57:496)

Clinical features
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● 80% present at age 50+
● Polyps present in stomach or colorectum; rarely small bowel
● Less pedunculated than other juvenile polyps
● May develop adenomas, adenocarcinoma

Symptoms:
● Diarrhea, weight loss, abdominal pain, weakness, anorexia
● 50% die of cachexia

Case reports
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● 78 year old man with weight loss, diarrhea, and altered sense of taste (Gastroenterol Hepatol (NY) 2012;8:197)

Micro description
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● Juvenile-type polyps, with cystically dilated glands in polyp and nonpolypoid mucosa
● No dysplasia

End of Small bowel (small intestine) > Benign tumors and tumor-like conditions > Cronkhite-Canada syndrome


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