Small bowel (small intestine)
Benign tumors and tumor-like conditions
Cronkhite-Canada syndrome

Topic Completed: 1 August 2012

Revised: 13 March 2019

Copyright: 2003-2019,, Inc.

PubMed Search: Cronkhite-Canada syndrome[TIAB] small bowel

Hanni Gulwani, M.B.B.S.
Page views in 2019: 348
Page views in 2020 to date: 34
Cite this page: Gulwani H. Cronkhite-Canada syndrome. website. Accessed February 18th, 2020.
Definition / general
  • Noninherited condition associated with high morbidity, characterized by GI hamartomatous polyposis, alopecia, onychodystrophy, hyperpigmentation, diarrhea (Dig Dis Sci 2012;57:496)
Clinical features
  • 80% present at age 50+
  • Polyps present in stomach or colorectum; rarely small bowel
  • Less pedunculated than other juvenile polyps
  • May develop adenomas, adenocarcinoma

  • Diarrhea, weight loss, abdominal pain, weakness, anorexia
  • 50% die of cachexia
Case reports
Microscopic (histologic) description
  • Juvenile type polyps, with cystically dilated glands in polyp and nonpolypoid mucosa
  • No dysplasia
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