Small bowel (small intestine)
Benign tumors and tumor-like conditions
Cronkhite-Canada syndrome

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 16 February 2018, last major update August 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Cronkhite-Canada syndrome[TIAB] small bowel

Cite this page: Gulwani, H. Cronkhite-Canada syndrome. website. Accessed October 15th, 2018.
Definition / general
  • Noninherited condition associated with high morbidity, characterized by GI hamartomatous polyposis, alopecia, onychodystrophy, hyperpigmentation, diarrhea (Dig Dis Sci 2012;57:496)
Clinical features
  • 80% present at age 50+
  • Polyps present in stomach or colorectum; rarely small bowel
  • Less pedunculated than other juvenile polyps
  • May develop adenomas, adenocarcinoma

  • Diarrhea, weight loss, abdominal pain, weakness, anorexia
  • 50% die of cachexia
Case reports
Microscopic (histologic) description
  • Juvenile type polyps, with cystically dilated glands in polyp and nonpolypoid mucosa
  • No dysplasia