Small bowel (small intestine)
Malabsorption
Dermatitis herpetiformis


Topic Completed: 1 August 2012

Revised: 8 March 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Dermatitis herpetiformis[TI] small bowel[TIAB]

See also: Skin - nontumor chapter
Page views in 2018: 286
Page views in 2019 to date: 187
Cite this page: Gulwani H. Dermatitis herpetiformis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/smallboweldermatitisherp.html. Accessed May 21st, 2019.
Definition / general
  • Usually present with skin manifestations only and are not aware of the underlying small bowel problems
  • Resembles celiac sprue - both respond to gluten free diet (skin lesions improve), both associated with HLA B8 and HLA DR3, both associated with lymphoma
  • Pruritic, papulovesicular lesions symmetrically distributed on scalp, buttocks, extremities, with granular deposition of IgG at epidermal dermal junctional
Diagnosis
Microscopic (histologic) description
  • Severe mucosal lesion on small bowel biopsy
  • May be patchy with variable villus abnormality
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