Small bowel (small intestine)
Enteroendocrine cell dysgenesis
Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 22 December 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.
● Enteroendocrine cells are part of body's largest endocrine system; secrete multiple regulatory molecules which control physiological and homeostatic functions, particularly postprandial secretion and motility (Therap Adv Gastroenterol 2008;1:51)
● Enteroendocrine cell dysgenesis is extremely rare (1 known paper) congenital life threatening malabsorptive condition (Stanford University)
● Defect is secondary to point mutations in NEUROG3, causing arrest of endocrine cell development in small intestine and colon (Hum Pathol 2007;38:570)
End of Small bowel (small intestine) > Malabsorption > Enteroendocrine cell dysgenesis
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