Small bowel (small intestine)
Other malignancies
Follicular dendritic cell sarcoma

Topic Completed: 1 August 2012

Revised: 15 March 2019

Copyright: 2003-2019,, Inc.

PubMed Search: Follicular dendritic cell sarcoma small bowel

Hanni Gulwani, M.B.B.S.
Page views in 2018: 717
Page views in 2019 to date: 719
Cite this page: Gulwani H. Follicular dendritic cell sarcoma. website. Accessed November 18th, 2019.
Definition / general
  • Rare tumor, first described in 1986 (Am J Pathol 1986;122:562)
  • Usually presents as painless, indolent mass (occasionally pain but without constitutional symptoms)
  • May be associated with Castleman disease - hyaline vascular type
  • Need immunostains for diagnosis
  • Usually lymph nodes, predominantly cervical, axillary or mediastinal (Am J Hematol 1998;59:161)
  • Extranodal sites include oral cavity, spleen, liver, small intestine, pancreas, peritoneum, soft tissue, skin
Poor prognostic factors
  • Large tumor size (6 cm or more), intraabdominal location and coagulative necrosis (Cancer 1997;79:294)
Case reports
  • Excision; often recurs locally, occasional distant metastases to liver or lung
Gross images

Case of the Week #81

Duodenal mass 10.5 x 10 cm

Microscopic (histologic) description
  • Storiform arrangement of oval or spindled cells, lymphocytic infiltrate
Microscopic (histologic) images

Case of the Week #81

Various images


Positive stains
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