Small bowel (small intestine)
Follicular lymphoma

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 22 February 2018, last major update August 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Follicular lymphoma[TIAB] small bowel

Cite this page: Gulwani, H. Follicular lymphoma. website. Accessed October 19th, 2018.
Definition / general
  • Common low grade lymphoma, often arises in terminal ileum or as small polypoid masses throughout bowel (lymphomatoid polyposis, which may also represent mantle cell lymphoma)
  • Either primary or secondary

Primary follicular lymphoma of small bowel:
  • Median age 54 years, 2/3 female
  • Small bowel is most common site in GI tract; duodenum > ileum > colon; often transmural involvement
  • Disease localized to bowel and regional lymph nodes in most cases (Am J Surg Pathol 2011;35:1255)
  • Indolent with occasional relapses but no / rare deaths, median disease free survival of 69 months (Am J Surg Pathol 2002;26:216)
  • Duodenal cases may be more common in women, are usually periampullary (Am J Surg Pathol 2000;24:688)
  • Distal small bowel involvement is more likely to present as bowel obstruction requiring resection
Gross description
  • Bowel thickening with multiple elevated nodules or plaques, possible bowel obstruction
Microscopic (histologic) description
  • Usually follicular growth pattern of small, cleaved, bland appearing lymphocytes
  • May transform to higher histologic grade
Microscopic (histologic) images

Images hosted on other servers:

Various images

Positive stains
Negative stains
Molecular / cytogenetics description