Small bowel (small intestine)
Benign tumors and tumor-like conditions

Topic Completed: 1 August 2012

Revised: 13 March 2019

Copyright: 2003-2019,, Inc.

PubMed Search: Ganglioneuroma small bowel

Hanni Gulwani, M.B.B.S.
Page views in 2019: 794
Page views in 2020 to date: 204
Cite this page: Gulwani H. Ganglioneuroma. website. Accessed March 29th, 2020.
Definition / general
  • Neural tumor, usually arises from nerves within bowel wall, may be mucosal
  • Multiple tumors are associated with neurofibromatosis type 1, MEN 2b / 3; sporadic tumors are usually solitary
Case reports
Gross description
  • Polypoid
Microscopic (histologic) description
  • Proliferation of ganglion cells and Schwann cells in mucosa and deeper layers
  • May see accentuation of submucosal and myenteric plexus in MEN 2b / 3
Microscopic (histologic) images

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Ganglioneuroma and ganglioneuromatosis: (A) solitary ganglioneuroma presents as a single polyp but (C) diffuse ganglioneuromatosis forms a flat, ill defined mass lesion; both solitary (B) and diffuse (D) ganglioneuromatosis contain ganglion and neoplastic Schwann cells

Positive stains
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