Small bowel (small intestine)
Benign tumors and tumor-like conditions

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 19 February 2018, last major update August 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Ganglioneuroma small bowel

Cite this page: Gulwani, H. Ganglioneuroma. website. Accessed October 20th, 2018.
Definition / general
  • Neural tumor, usually arises from nerves within bowel wall, may be mucosal
  • Multiple tumors are associated with neurofibromatosis type 1, MEN 2b / 3; sporadic tumors are usually solitary
Case reports
Gross description
  • Polypoid
Microscopic (histologic) description
  • Proliferation of ganglion cells and Schwann cells in mucosa and deeper layers
  • May see accentuation of submucosal and myenteric plexus in MEN 2b / 3
Microscopic (histologic) images

Images hosted on other servers:

Ganglioneuroma and ganglioneuromatosis: (A) solitary ganglioneuroma presents as a single polyp but (C) diffuse ganglioneuromatosis forms a flat, ill defined mass lesion; both solitary (B) and diffuse (D) ganglioneuromatosis contain ganglion and neoplastic Schwann cells

Positive stains