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Small bowel (small intestine)

Other malignancies

Kaposi sarcoma

Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 22 December 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Present in GI tract in 50% with AIDS, although symptoms in only 10% (diarrhea, protein-losing enteropathy, abdominal pain)

Case reports
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● 35 year old man with jejunal tumor (Rev Gastroenterol Peru 2005;25:285)
● 37 year old man with tumor of stomach and duodenum (Dig Endosc 2010;22:241)
● 39 year old and 74 year old patients with stomach and small bowel tumors (Pathol Res Pract 2007;203:227)

Gross description
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● Multiple red-brown or purple nodules, 5-15 mm

Gross images
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Various images

Micro description
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● Spindle cells that expand lamina propria and obliterate muscularis mucosa, extravasated red blood cells
● Often submucosal involvement

Micro images
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Kaposi sarcoma involving duodenal lamina propri; submucosal involvement is more common

Kaposi sarcoma of stomach, showing characteristic eosinophilic cytoplasmic inclusions (arrowheads), which may represent residua of phagocytosed red cells; inclusions are 60% sensitive for Kaposi sarcoma and relatively specific

Positive stains
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● CD34, CD31

Negative stains
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● S100, desmin, muscle specific actin

End of Small bowel (small intestine) > Other malignancies > Kaposi sarcoma

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