Small bowel (small intestine)
Benign tumors and tumor-like conditions

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 20 February 2018, last major update August 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Mastocytosis small bowel

Cite this page: Gulwani, H. Mastocytosis. website. Accessed October 19th, 2018.
Definition / general
  • Rare systemic disorder with mast cells in skin, bones, lymph nodes, other organs
  • 50% involve GI tract and may cause malabsorption
  • Rarely involves small bowel without skin involvement
  • Consider diagnosis if 6+ mast cells present per high power field
  • Immunoreactivity for CD25 in GI mucosal mast cells is specific for systemic mastocytosis and can be used to confirm the diagnosis (Am J Surg Pathol 2007;31:1669)
Case reports
Microscopic (histologic) description
  • Variable villus abnormality with increased mast cells or eosinophils
Microscopic (histologic) images

Images hosted on other servers:

Various images (not necessarily small bowel)

Positive stains