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Small bowel (small intestine)

Benign tumors and tumor-like conditions

Mastocytosis

Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 22 December 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Rare systemic disorder with mast cells in skin, bones, lymph nodes, other organs
● 50% involve GI tract and may cause malabsorption
● Rarely involves small bowel without skin involvement
● Consider diagnosis if 6+ mast cells present per high power field
● Immunoreactivity for CD25 in GI mucosal mast cells is specific for Systemic Mastocytosis and can be used to confirm the diagnosis (Am J Surg Pathol 2007;31:1669)

Case reports
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● Mast cell sarcoma of small intestine (J Clin Pathol 2011;64:1035)
● Systemic mastocytosis mimicking inflammatory bowel disease (Am J Surg Pathol 2006;30:1478)

Micro description
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● Variable villus abnormality with increased mast cells or eosinophils

Micro images
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Various images (not necessarily small bowel)

Positive stains
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● Mast cell tryptase, CD117, CD25

Additional references
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● World J Gastroenterol 2008;14:7005, Am J Clin Pathol 2004;122:560

End of Small bowel (small intestine) > Benign tumors and tumor-like conditions > Mastocytosis

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