Small bowel (small intestine)
Mantle cell lymphoma

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 22 February 2018, last major update August 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Mantle cell lymphoma small bowel

Cite this page: Gulwani, H. Mantle cell lymphoma. website. Accessed October 19th, 2018.
Definition / general
Clinical features
  • 88% males, mean age 61 years
  • Weight loss, fatigue, diarrhea, abdominal pain, often iron deficiency
  • Mean survival less than 3 years
  • May begin as single lesion or with disseminated multiple mucosal involvement (Mod Pathol 2001;14:811)
Case reports
Gross description
  • Nodular, sessile or polypoid lesions, widely spaced with confluent studded or cobblestone appearance
  • Each polyp 2 mm to 2 cm
  • May be dominant tumor mass in ileocecum
Microscopic (histologic) description
  • Infiltrative mantle cells (small lymphocytes with cleaved irregular nuclei) with invasion of submucosa, sparing of mucosa
  • Epithelial invasion and ulceration occurs late in disease
  • Secondary intestinal dissemination by lymph node based mantle cell lymphoma is exceedingly common; has a lymphomatous polyposis pattern with involvement of colon (Am J Surg Pathol 1996;20:442)
Microscopic (histologic) images

Images hosted on other servers:

Tumor of terminal ileum / colon (figs 2, 3)

Positive stains
Negative stains
Differential diagnosis