Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Small bowel (small intestine)

Other malignancies

Metastases


Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 22 December 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
=========================================================================

● Often appear as multiple polypoid tumors causing obstruction or perforation
● Usually melanoma (see below), lung carcinoma, breast carcinoma, choriocarcinoma

Case reports
=========================================================================

● 21 year old man with osteosarcoma metastases presenting as small bowel polyp (Arch Pathol Lab Med 2000;124:1682)
● 61 year old woman with leiomyosarcoma causing intussusception (Arch Pathol Lab Med 2000;124:169)

Gross images
=========================================================================



Osteosarcoma metastatic to jejunum


Metastasis-site of origin not specified


Gall bladder carcinosarcoma: metastatic to small bowel (courtesy Dr. Semir Vranic, University of Sarajevo, Bosnia and Herzegovina)

Micro images
=========================================================================



Metastatic leiomyosarcoma


Metastatic osteosarcoma


Melanoma metastatic to small bowel

General
=========================================================================

● Often long period between primary and metastatic diagnosis
● Better prognosis if solitary versus multiple metastases

Case reports
=========================================================================

● 17 year old man and 60 year old woman with metastatic cutaneous melanomas (Int J Surg Case Rep 2012;3:395)

Gross images
=========================================================================



Metastatic cutaneous melanoma to jejunum

Micro description
=========================================================================

● Undifferentiated tumor with discohesive cells with pink cytoplasm, pleomorphic nuclei, macronucleoli, frequent mitotic figures
● Spindled or epithelioid cells

Micro images
=========================================================================



Melanoma from thigh of 50 year old Bosnian man metastatic to jejunum (H&E, S100, MelanA), courtesy of Dr. Semir Vranic, University of Sarajevo, Bosnia and Herzegovina


Various images

Positive stains
=========================================================================

● S100, HMB45, MelanA/Mart1

Negative stains
=========================================================================

● CD117, CD34, smooth muscle actin

End of Small bowel (small intestine) > Other malignancies > Metastases


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).