Small bowel (small intestine)

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Small bowel (small intestine)

Other malignancies

Metastases

Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 22 December 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Often appear as multiple polypoid tumors causing obstruction or perforation
● Usually melanoma (see below), lung carcinoma, breast carcinoma, choriocarcinoma

Case reports
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● 21 year old man with osteosarcoma metastases presenting as small bowel polyp (Arch Pathol Lab Med 2000;124:1682)
● 61 year old woman with leiomyosarcoma causing intussusception (Arch Pathol Lab Med 2000;124:169)

Gross images
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Osteosarcoma metastatic to jejunum

Metastasis-site of origin not specified

Gall bladder carcinosarcoma: metastatic to small bowel (courtesy Dr. Semir Vranic, University of Sarajevo, Bosnia and Herzegovina)

Micro images
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Metastatic leiomyosarcoma

Metastatic osteosarcoma

Melanoma metastatic to small bowel

General
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● Often long period between primary and metastatic diagnosis
● Better prognosis if solitary versus multiple metastases

Case reports
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● 17 year old man and 60 year old woman with metastatic cutaneous melanomas (Int J Surg Case Rep 2012;3:395)

Gross images
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Metastatic cutaneous melanoma to jejunum

Micro description
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● Undifferentiated tumor with discohesive cells with pink cytoplasm, pleomorphic nuclei, macronucleoli, frequent mitotic figures
● Spindled or epithelioid cells

Micro images
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Melanoma from thigh of 50 year old Bosnian man metastatic to jejunum (H&E, S100, MelanA), courtesy of Dr. Semir Vranic, University of Sarajevo, Bosnia and Herzegovina

Various images

Positive stains
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● S100, HMB45, MelanA/Mart1

Negative stains
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● CD117, CD34, smooth muscle actin

End of Small bowel (small intestine) > Other malignancies > Metastases

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