Small bowel (small intestine)
Infectious disorders
Microsporidia

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 14 February 2018, last major update August 2012

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Microsporidia small bowel

Cite this page: Gulwani, H. Microsporidia. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/smallbowelmicrosporidiosis.html. Accessed October 19th, 2018.
Definition / general
  • Caused by Enterocytozoon bieneusi, an obligate intracellular protozoan that affects only enterocytes and Encephalitozoon intestinalis, which infects macrophages, fibroblasts, endothelial cells, enterocytes
  • Both cause chronic diarrhea in patients with immunosuppression, HIV
Diagnosis
  • Stool examination, PCR
Case reports
Treatment
  • Albendozole for E. intestinalis, nothing for E. bieneusi
Microscopic (histologic) description
  • Minimal / no changes in mucosa but can find development spores as 1.5 mm dots in enterocytes
  • May be surrounded by halos
  • Also nucleated sporont present as 3 - 5 micron, rounded, basophilic structure often surrounded by a halo
Microscopic (histologic) images

Images hosted on other servers:

Various images

Positive stains
Electron microscopy description
  • Often helpful for diagnosis