Small bowel (small intestine)
Malabsorption
Microvillus inclusion disease


Topic Completed: 1 August 2012

Revised: 8 March 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Microvillus inclusion disease small bowel

Hanni Gulwani, M.B.B.S.
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Cite this page: Gulwani H. Microvillus inclusion disease. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/smallbowelmicrovillusinclusiondisease.html. Accessed October 21st, 2019.
Definition / general
  • Also called congenital or familial microvillous atrophy
  • Disorder of intestinal brush border that causes intractable watery diarrhea with steatorrhea in infants
  • Patients require total parental nutrition and rarely live beyond age 2 years
  • Villous atrophy may be due to apoptotic cell loss (Hum Pathol 2000;31:1404)
Treatment
  • Small bowel transplant
Microscopic (histologic) description
  • Severe villous abnormality with crypt hypoplasia, resembling celiac sprue but without lymphocytosis
  • Increased enterocyte apoptosis and proliferation, bubbly vacuolated apical cytoplasm with extensive or patchy absence of brush border, absence of inflammation (Ultrastruct Pathol 2010;34:327)
Microscopic (histologic) images

Images hosted on other servers:

Various images

Positive stains
Electron microscopy description
  • Abnormal microvillus structures at luminal border of enterocytes
  • Apical intracytoplasmic inclusions lined by microvilli
Electron microscopy images

Images hosted on other servers:

Neonatal congenital microvillus atrophy

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