Small bowel (small intestine)
Microvillus inclusion disease

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 12 February 2018, last major update August 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Microvillus inclusion disease small bowel

Cite this page: Gulwani, H. Microvillus inclusion disease. website. Accessed December 13th, 2018.
Definition / general
  • Also called congenital or familial microvillous atrophy
  • Disorder of intestinal brush border that causes intractable watery diarrhea with steatorrhea in infants
  • Patients require total parental nutrition and rarely live beyond age 2 years
  • Villous atrophy may be due to apoptotic cell loss (Hum Pathol 2000;31:1404)
  • Small bowel transplant
Microscopic (histologic) description
  • Severe villous abnormality with crypt hypoplasia, resembling celiac sprue but without lymphocytosis
  • Increased enterocyte apoptosis and proliferation, bubbly vacuolated apical cytoplasm with extensive or patchy absence of brush border, absence of inflammation (Ultrastruct Pathol 2010;34:327)
Microscopic (histologic) images

Images hosted on other servers:

Various images

Positive stains
Electron microscopy description
  • Abnormal microvillus structures at luminal border of enterocytes
  • Apical intracytoplasmic inclusions lined by microvilli
Electron microscopy images

Images hosted on other servers:

Neonatal congenital microvillus atrophy