Home   Chapter Home   Jobs   Conferences   Fellowships   Books


Small bowel (small intestine)

Inflammatory disorders

Radiation enterocolitis

Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 15 December 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.


● Observed acutely or years after radiation therapy for cervical carcinoma, Wilm’s tumor, lymphoma or other peritoneal tumors

Clinical features

● Acute: anorexia, cramps, diarrhea due to mucosal injury and malabsorption
● Chronic: may present as inflammatory colitis or indolent; also vascular injury, ischemic fibrosis, stricture
● Treatment: resection if severe

Gross description

● Thickened bowel wall

Micro description

● Varies from mild epithelial damage to massive necrosis and ulceration (BMC Surg 2004;4:10)
● Loss of columnar shape and nuclear polarity of enterocytes, nuclear pyknosis, bizarre nuclei, mucin depletion and decreased mitoses
● Also fibroblasts and endothelium with submucosal edema but low nuclear to cytoplasmic ratio, preservation of architecture
● No desmoplasia, no infiltrative pattern

● Atrophic and ulcerated mucosa, ectatic blood vessels, fibrosis of submucosa and muscular wall, vascular wall thickening, vascular stenosis
● Possible fistula formation, atherosclerosis-like changes of vasculature (subintimal lipid-laden macrophages, calcification, thrombosis), hyalinization of lamina propria

Micro images

Acute changes (mice)

End of Small bowel (small intestine) > Inflammatory disorders > Radiation enterocolitis

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).