Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Small bowel (small intestine)

Benign tumors and tumor-like conditions

Reactive nodular fibrous pseudotumor


Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 22 December 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
=========================================================================

● First described in 2003 in 5 patients (4 men), mean age 56 years (Am J Surg Pathol 2003;27:532)
● May present as obstruction (Am Surg 2011;77:790), but otherwise benign clinical course

Gross description
=========================================================================

● Firm, tan-white, 4-6 cm, solitary/multiple, in small bowel or colon

Micro description
=========================================================================

● Low/moderate cellularity
● Spindled fibroblasts arranged haphazardly or in intersecting fascicles
● Often infiltrative borders
● Stroma rich in wire-like, keloidal or hyalinized collagen
● Peripheral lymphoid aggregates

Positive stains
=========================================================================

● Vimentin, CD117 or muscle specific actin (80%), smooth muscle actin or desmin (60%) (Int J Surg Pathol 2004;12:365)

Negative stains
=========================================================================

● CD34, S100, ALK1

Differential diagnosis
=========================================================================

Fibromatosis

End of Small bowel (small intestine) > Benign tumors and tumor-like conditions > Reactive nodular fibrous pseudotumor


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).