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Small bowel (small intestine)

Inflammatory disorders

Sarcoidosis


Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 15 December 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Multisystemic disorder of unknown cause characterized by noncaseating granulomas in involved organs (Orphanet J Rare Dis 2007 Nov 19;2:46); usually does NOT involve the small bowel (QJM 2010;103:60)
● Must rule out Crohn’s disease before making this diagnosis
● Presents with malabsorption, protein losing enteropathy and lymphangiectasia secondary to lymphatic obstruction

Case reports
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● 36 year old woman with 10 kg weight loss (Rev Med Interne 2010;31:262)

Clinical images
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Gastrocopy shows duodenal granulomatous involvement

Micro description
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● Compact bland noncaseating granulomas that involve bowel wall and regional nodes
● Must rule out Crohn's disease
● Negative stains / PCR for fungi, AFB

Micro images
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Various images

End of Small bowel (small intestine) > Inflammatory disorders > Sarcoidosis


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