Small bowel (small intestine) - Small cell carcinoma

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Small bowel (small intestine)

Carcinoma

Small cell carcinoma

Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 12 December 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Rare, in few cases reported, prognosis better than for small cell lung tumors

Micro description
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● Sheets and nests of small, round cells with scanty cytoplasm, hyperchromatic nuclei, stippled chromatin, indistinct nucleoli, numerous mitotic figures and apoptotic cells
● Foci of necrosis and vascular invasion common
● Resembles pulmonary tumor
● Pure or mixed with adenocarcinoma

Micro images
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Tumor of proximal ileum; figure 4 is synaptophysin

Positive stains
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● Neuroendocrine markers, CK8, may be TTF1 positive

Electron microscopy description
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● Membrane-bound dense core granules

Additional references
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● Arch Pathol Lab Med 2003;127:e357, J Clin Oncol 2004;22:2730, J Clin Pathol 2010;63:620

End of Small bowel (small intestine) > Carcinoma > Small cell carcinoma

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