Small bowel (small intestine)
Staging - neuroendocrine tumors

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 27 February 2018, last major update August 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Staging neuroendocrine tumors small bowel[TIAB]

Cite this page: Gulwani, H. Staging - neuroendocrine tumors. website. Accessed July 15th, 2018.
Definition / general
  • Click here for staging of ampullary tumors
Primary tumor (T)
  • TX: Primary tumor cannot be assessed
  • T0: No evidence for primary tumor
  • T1: Tumor invades lamina propria or submucosa and size 1 cm or less
  • T2: Tumor invades muscularis propria or size > 1 cm
  • T3: Tumor invades through the muscularis propria into subserosal tissue without penetration of overlying serosa (jejunal or ileal tumors) or invades pancreas or retroperitoneum (ampullary or duodenal tumors) or into nonperitonealized tissues
  • T4: Tumor invades visceral peritoneum (serosa) or invades other organs

  • For any T, add (m) for multiple tumors
Regional lymph nodes (N)
  • NX: Regional lymph nodes cannot be assessed
  • N0: No regional lymph node metastasis
  • N1: Regional lymph node metastasis

  • For duodenal tumors, the regional lymph nodes are duodenal, hepatic, pancreaticoduodenal, infrapyloric, gastroduodenal, pyloric, superior mesenteric, pericholedochal nodes
  • For ileal and jejunal tumors, the regional lymph nodes are the cecal (for tumors arising in the terminal ileum), superior mesenteric, mesenteric nodes
  • Metastases to celiac nodes are considered distant metastases
Distant metastasis (M)
  • M0: No distant metastasis
  • M1: Distant metastasis
Anatomic stage / prognostic groups
  • Stage I: T1 N0 M0
  • Stage IIA: T2 N0 M0
  • Stage IIB: T3 N0 M0
  • Stage IIIA: T4 N0 M0
  • Stage IIIB: Any T N1 M0
  • Stage IV: M1 (any T, any N)