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Small bowel (small intestine)



Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 22 December 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.


● Acute changes associated with transplantation (not rejection) are epithelial denudation, crypt regeneration, mild acute inflammation

Acute cellular rejection

● Occurs weeks to months after transplantation
● Resembles graft vs. host disease with increase in lymphocytes in lymphoid tissues
● Crypt epithelial damage and apoptosis, chronic inflammation in lamina propria, epithelial lymphocytosis, lymphocytic infiltration of vessels

Chronic rejection

● Fibrosis of bowel wall, vascular sclerosis
● May develop post-transplantation lymphoproliferative disorders associated with EBV infection
● Rejection is monitored by mucosal biopsy

End of Small bowel (small intestine) > Miscellaneous > Transplantation

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