Small bowel (small intestine)
Miscellaneous
Transplantation

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 27 February 2018, last major update August 2012

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Transplantation[TI] small bowel[TI] free full text[sb]

Cite this page: Gulwani, H. Transplantation. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/smallboweltransplantation.html. Accessed July 15th, 2018.
Definition / general
  • Acute changes associated with transplantation (not rejection) are epithelial denudation, crypt regeneration, mild acute inflammation
Acute cellular rejection
  • Occurs weeks to months after transplantation
  • Resembles graft versus host disease with increase in lymphocytes in lymphoid tissues
  • Crypt epithelial damage and apoptosis, chronic inflammation in lamina propria, epithelial lymphocytosis, lymphocytic infiltration of vessels
Chronic rejection
  • Fibrosis of bowel wall, vascular sclerosis
  • May develop posttransplantation lymphoproliferative disorders associated with EBV infection
  • Rejection is monitored by mucosal biopsy