Small bowel (small intestine)
Miscellaneous
Transplantation


Topic Completed: 1 August 2012

Revised: 15 March 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Transplantation[TI] small bowel[TI] free full text[sb]

Hanni Gulwani, M.B.B.S.
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Cite this page: Gulwani H. Transplantation. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/smallboweltransplantation.html. Accessed November 20th, 2019.
Definition / general
  • Acute changes associated with transplantation (not rejection) are epithelial denudation, crypt regeneration, mild acute inflammation
Acute cellular rejection
  • Occurs weeks to months after transplantation
  • Resembles graft versus host disease with increase in lymphocytes in lymphoid tissues
  • Crypt epithelial damage and apoptosis, chronic inflammation in lamina propria, epithelial lymphocytosis, lymphocytic infiltration of vessels
Chronic rejection
  • Fibrosis of bowel wall, vascular sclerosis
  • May develop posttransplantation lymphoproliferative disorders associated with EBV infection
  • Rejection is monitored by mucosal biopsy
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