Small bowel (small intestine)
Malabsorption
Tropical sprue


Topic Completed: 1 August 2012

Revised: 8 March 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Tropical sprue[TI] small bowel full text[sb]
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Cite this page: Gulwani H. Tropical sprue. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/smallboweltropicalsprue.html. Accessed March 21st, 2019.
Definition / general
  • Also called postinfectious sprue
  • Affects people living in or visiting the tropics, particularly Caribbean (not Jamaica), Africa, India, Southeast Asia, Central / South America (Case Rep Gastroenterol 2010;4:168)
  • Has endemic and epidemic features
  • May be due to E. coli or Haemophilus
  • Symptoms: malabsorption within weeks of acute diarrheal enteric infection
Treatment
  • Broad spectrum antibiotics (tetracycline), folic acid, vitamin B12
  • No increased risk of intestinal lymphoma
Microscopic (histologic) description
  • Variable villous atrophy (none, partial, total)
  • Injury to entire small bowel (not proximal as in celiac sprue), inflammatory infiltrate, crypt hyperplasia
Microscopic (histologic) images

Images hosted on other servers:

Various images



Contributed by Dr. Hanni Gulwani

40 year old man with chronic diarrhea who improved after antibiotics; marked villous atrophy in duodenal biopsy but no increase in intraepithelial lymphocytes

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