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Small bowel (small intestine)

Infectious disorders

Tuberculosis


Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 17 December 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Disease occasionally seen in less developed countries
● Small intestinal disease may be transmitted via contaminated milk
Symptoms: abdominal pain, malabsorption, strictures, perforation, fistula

Sites
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● Terminal ileum, cecum, appendix

Gross description
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● Multiple and circumferential ulcers and strictures

Micro description
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● Confluent granulomas with central necrosis and peripheral lymphocytosis
● Destruction of muscularis propria, scarring

Micro images
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Granulomas in mucosa and submucosa


Ileocecal tuberculosis in 45 year old woman; epithelioid granulomas with Langhan’s giant cells in lamina propria (courtesy of Dr. Hanni Gulwani)


Ileocecal tuberculosis and adjoining draining lymph node (courtesy of Dr. Hanni Gulwani)

Positive stains
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● Acid-fast stains

Differential diagnosis
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Crohn’s disease: linear and serpiginous ulcers; no bacteria identified (World J Gastroenterol 2011;17:433, BMJ Case Rep 2009;2009.1729)

End of Small bowel (small intestine) > Infectious disorders > Tuberculosis


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