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Small bowel (small intestine)

Patterns of abnormal small bowel architecture

Variable villus abnormality and crypt hypoplasia

Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 14 December 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Villi focally flat or mild/moderate villus shortening
● Also increased intraepithelial lymphocytosis, decreased crypt mitotic figures

Etiology
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● Marasmus: severe protein-calorie malnutrition
● Kwashiorkor: protein malnutrition but adequate caloric intake
● Megaloblastic anemia: vitamin B12 or folate deficiency, no increased inflammatory cells
● Chemoradiation effect: apoptosis, atypical cells
● Microvillus inclusion disease

End of Small bowel (small intestine) > Patterns of abnormal small bowel architecture > Variable villus abnormality and crypt hypoplasia

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