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Soft Tissue Tumors Part 3
Muscle, Vascular, Nerve, Other
Genital leiomyoma
Author: Nat Pernick, M.D, PathologyOutlines.com, Inc.
Revised: 9 August 2009, last major update - August 2009
Copyright: (c) 2002-2009, PathologyOutlines.com, Inc.
Leiomyoma: classic, bizarre, cutaneous, epithelioid, genital
See also: leiomyoma of deep soft tissue
Definition
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● Arises from smooth muscle (dartos) bundles in superficial subcutaneous tissue or related structures of genitalia (penis / scrotum, labia, anal skin) or areola / nipple
Clinical
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● Solitary
Case reports
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● Tumor of female nipple (Breast J 2006;12:377)
● 25 year old woman with large labial tumor (J Med Assoc Thai 2005;88:118)
● 47 year old man with scrotal tumor (The Internet Journal of Dermatology 2009 Volume 7 Number 1)
● 53 year old man with tumor of epididymis (Kaohsiung J Med Sci 2006;22:519)
● 61 year old man with nipple leiomyoma (Dermatology Online Journal 11 (1): 20)
Clinical images
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Tumor of male nipple
Micro
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● Has classic features of leiomyoma, but may also be cellular, epithelioid or myxoid
● Suggested classification for vulvar tumors is based on number of features below (0-1: leiomyoma, 2: atypical leiomyoma, 3-4: leiomyosarcoma)
(a) 5+ cm in greatest dimension
(b) infiltrative margins
(c) 5+ mitotic figures per 10 hpf
(d) moderate to severe cytologic atypia (AJSP 1996;20:779)
Micro images
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Male nipple tumor Desmin staining: low and high power
End of Soft Tissue Tumors Part 3 - Muscle, Vascular, Nerve, Other > Genital leiomyoma
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