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Soft Tissue Tumors

Infections, inflammation and hematomas

PVP granuloma

Reviewer: Komal Arora, M.D. (see Reviewers page)
Revised: 18 July 2012, last major update July 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.


Definition: granuloma due to injection of drugs containing polyvinylpyrrolidone (PVP)
● Rare (Am J Surg Pathol 1984;8:393)

Micro description

● Focal cellularity, focally myxoid with foamy histiocytes containing vacuoles and PVP

Positive stains

Histiocytes: mucicarmine, colloidal iron, GMS, Congo Red, Sudan Black B

Differential diagnosis

● Myxoid liposarcoma
● Signet ring carcinoma

End of Soft Tissue Tumors > Infections, inflammation and hematomas > PVP granuloma

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