Soft tissue
Adipose tissue tumors
Lipoma and variants

Topic Completed: 1 August 2012

Minor changes: 24 September 2020

Copyright: 2002-2020,, Inc.

PubMed Search: Angiolipoma

See also: Breast chapter

Vijay Shankar, M.D.
Page views in 2019: 13,617
Page views in 2020 to date: 9,400
Cite this page: Shankar, V. Angiolipoma. website. Accessed October 24th, 2020.
Definition / general
  • Subcutaneous nodule composed of mature adipocytes, thin walled vessels and fibrin thrombi
  • Arises shortly before puberty or in young adults
  • Rare in children or older adults
  • 5% familial
Clinical features
  • Usually skin, 2/3 in forearm and chest wall, can occur on thighs, distal extremity
  • Rarely in the head and neck region
  • Painful, usually multiple subcutaneous nodules (other painful nodules are angioleiomyoma, eccrine spiradenoma, glomus tumor and traumatic neuroma)
  • May actually be hemangioma containing fat, not a mixed tumors
Case reports
  • Excision
  • Does not recur or metastasize
Clinical images

Images hosted on other servers:

Soft nodular mass


Clinical featuring

Gross description
  • Encapsulated, small (< 2 cm), yellow-red nodule in subcutaneous tissue
Gross images

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Lesion and its microscopic appearance

Yellowish in color

Thin fibrous septae and brown spots

Microscopic (histologic) description
  • Mature adipose tissue, branching capillaries and thick walled vessels with pericytes, particularly at periphery
  • Hyaline / fibrin thrombi are an important diagnostic sign
  • Cellular tumors are usually encapsulated with septation and fibrin thrombi (Am J Surg Pathol 1990;14:75)
  • Mast cells are present
  • Fibrosis in older lesions
Microscopic (histologic) images

Contributed by Mark R. Wick, M.D.

Various images

AFIP images

Mature adipose and proliferated vascular tissue

Images hosted on other servers:

Mature adipose and proliferated vascular tissue

Mature adipose tissue and prominent vasculature

Prominent vascular thrombi

9 year old girl with lesion on lip

Various images

Angiolipoma of the muscle

Electron microscopy description
Molecular / cytogenetics description
  • Almost always normal karyotype
Differential diagnosis
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