Soft tissue
Adipose tissue

Author: Vijay Shankar, M.D. (see Authors page)

Revised: 28 July 2016, last major update August 2012

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Angiolipoma

See also: Breast chapter

Cite this page: Angiolipoma. website. Accessed October 21st, 2016.
Definition / General
  • Subcutaneous nodule composed of mature adipocytes, thin walled vessels and fibrin thrombi
  • Arises shortly before puberty or in young adults
  • Rare in children or older adults
  • 5% familial
Clinical Features
  • Usually skin, 2 / 3 in forearm and chest wall, can occur on thighs, distal extremity
  • Rarely in the head and neck region
  • Painful, usually multiple subcutaneous nodules (other painful nodules are angioleiomyoma, eccrine spiradenoma, glomus tumor and traumatic neuroma)
  • May actually be hemangioma containing fat, not a mixed tumors
Case Reports
  • Excision
  • Does not recur or metastasize
Clinical Images

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Soft nodular mass


Clinical featuring

Gross Description
  • Encapsulated, small (< 2 cm), yellow-red nodule in subcutaneous tissue
Gross Images

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Lesion and its microscopic appearance

Yellowish in color

Thin fibrous septae and brown spots

Micro Description
  • Mature adipose tissue, branching capillaries and thick walled vessels with pericytes, particularly at periphery
  • Hyaline / fibrin thrombi are an important diagnostic sign
  • Cellular tumors are usually encapsulated with septation and fibrin thrombi (Am J Surg Pathol 1990;14:75)
  • Mast cells are present
  • Fibrosis in older lesions
Micro Images

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Courtesy of Mark R. Wick, M.D.

Mature adipose and proliferated vascular tissue

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Mature adipose and proliferated vascular tissue

Mature adipose tissue and prominent vasculature

Prominent vascular thrombi

9 year old girl with lesion on lip

Various images

Courtesy of Semir Vranic, M.D.

Virtual Slides

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Electron Microscopy Description
Molecular / Cytogenetics Description
  • Almost always normal karyotype
Differential Diagnosis