Soft tissue
Adipose tissue
Hemosiderotic fibrohistiocytic lipomatous lesion

Author: Vijay Shankar, M.D. (see Authors page)

Revised: 8 August 2016, last major update August 2012

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Hemosiderotic fibrohistiocytic lipomatous lesion

Cite this page: Hemosiderotic fibrohistiocytic lipomatous lesion. website. Accessed October 28th, 2016.
Definition / General
  • Superficial benign fatty lesion, usually of foot / ankle, with CD34+ spindle cells and abundant hemosiderin
  • Possibly a reactive lesion
  • Not a WHO diagnosis
Case Reports
  • Radical surgical excision and follow up
  • May recur locally
  • No metastases or deaths
Gross Description
  • Mean 8 cm (range, 2 - 17 cm), solid and circumscribed but not encapsulated
Micro Description
  • Unencapsulated circumscribed superficial fatty lesion with CD34+ spindle cells and abundant hemosiderin (Stanford University)
  • Spindle cells have vesicular nuclei and indistinct nucleoli with occasional hyperchromatism
  • Inflammatory background
  • No / minimal atypia
Micro Images

Images hosted on PathOut servers:

Case of the Week #199

Images hosted on other servers:

Various images

Images hosted on Nature servers:

Hemosiderotic fibrohistiocytic lipomatous lesion (HFLL)

Positive Stains
Negative Stains