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Soft Tissue Tumors

Myxoid lipoma

 

Author: Nat Pernick, M.D., PathologyOutlines.com, Inc.

Reviewer: David Lucas, M.D., University of Michigan Health Systems (January 2009)

Revised: 14 June 2009, last major update June 2009

 

Definition

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● Lipoma with well developed myxoid areas

 

Terminology

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● Also called myxolipoma

● Not a WHO diagnosis

 

Epidemiology

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● Uncommon

● Some cases may actually be spindle cell lipomas (Am J Dermatopathol 2006;28:28)

 

Micro description

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● Lipoma with well developed myxoid areas

● No atypia, no plexiform vascular network, no lipoblasts

 

Positive stains

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● Oil red O (strong cytoplasmic staining on frozen tissue)

Mucoid material - PAS+ diastase resistant, Alcian Blue+

 

Electron microscopy

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● Adipocytes in various stages of differentiation with mature cells surrounded by basal lamina, lipid globules of varying size, pinocytotic vesicles in plasma membrane (Oral Surg Oral Med Oral Pathol 1984;57:300)

 

Differential Diagnoses

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● Myxoid liposarcoma - not in subcutaneous tissue, no classic lipoma areas, has lipoblasts and plexiform vascular pattern

 

End of Soft Tissue Tumors > Myxoid lipoma

 

 

 

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