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Soft Tissue Tumors
Myxoid lipoma
Author: Nat Pernick, M.D., PathologyOutlines.com, Inc.
Reviewer: David Lucas, M.D., University of Michigan Health Systems (January 2009)
Revised: 14 June 2009, last major update June 2009
Definition
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● Lipoma with well developed myxoid areas
Terminology
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● Also called myxolipoma
● Not a WHO diagnosis
Epidemiology
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● Uncommon
● Some cases may actually be spindle cell lipomas (Am J Dermatopathol 2006;28:28)
Micro description
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● Lipoma with well developed myxoid areas
● No atypia, no plexiform vascular network, no lipoblasts
Positive stains
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● Oil red O (strong cytoplasmic staining on frozen tissue)
● Mucoid material - PAS+ diastase resistant, Alcian Blue+
Electron microscopy
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● Adipocytes in various stages of differentiation with mature cells surrounded by basal lamina, lipid globules of varying size, pinocytotic vesicles in plasma membrane (Oral Surg Oral Med Oral Pathol 1984;57:300)
Differential Diagnoses
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● Myxoid liposarcoma - not in subcutaneous tissue, no classic lipoma areas, has lipoblasts and plexiform vascular pattern
End of Soft Tissue Tumors > Myxoid lipoma
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