Soft Tissue Tumors - Myxoid lipoma

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Soft Tissue Tumors

Adipose tissue

Myxoid lipoma

Reviewer: Vijay Shankar, M.D. (see Reviewers page)
Revised: 4 November 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Lipoma with well developed myxoid areas

Terminology
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● Also called myxolipoma
● Not a WHO diagnosis

Epidemiology
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● Uncommon
● Some cases may actually be spindle cell lipomas (Am J Dermatopathol 2006;28:28)

Case reports
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● 57 year old man with tender elbow mass (J Med Case Rep 2011;5:321)

Micro description
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● Lipoma with well developed myxoid areas
● No atypia, no plexiform vascular network, no lipoblasts

Micro images
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Adipocytes interspersed with deposition of mucin, and myxoid change

Positive stains
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● Oil Red O (strong cytoplasmic staining on frozen tissue)
● Mucoid material: PAS+ diastase resistant, Alcian Blue+

Electron microscopy description
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● Adipocytes in various stages of differentiation with mature cells surrounded by basal lamina, lipid globules of varying size, pinocytotic vesicles in plasma membrane (Oral Surg Oral Med Oral Pathol 1984;57:300)

Differential diagnosis
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● Myxoid liposarcoma: not in subcutaneous tissue, no classic lipoma areas, has lipoblasts and plexiform vascular pattern

End of Soft Tissue Tumors > Adipose tissue > Myxoid lipoma

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