Soft tissue
Adipose tissue
Myxoid / round cell liposarcoma - general

Author: Vijay Shankar, M.D. (see Authors page)

Revised: 9 August 2016, last major update August 2012

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Myxoid / round cell liposarcoma

Cite this page: Myxoid / round cell liposarcoma - general. website. Accessed October 24th, 2016.
  • #2 most common subtype of liposarcoma (33 - 50% of cases), after well differentiated liposarcoma
  • Adults in 20’s to 40’s
  • Rare in children under 10 years
  • Usually limb or thigh in muscle or deep tissue
  • Almost never retroperitoneal, only rarely in subcutis
  • Either well differentiated / low grade (well differentiated) or poorly differentiated / high grade (round cell)
  • Wide local excision, possibly radiotherapy (Cancer 2009;115:3254) or chemotherapy to prevent recurrence
  • Poor prognostic factors include poorly differentiated (round cell) component, large size, necrosis, high Ki-67 (J Clin Pathol 2003;56:579), p53 overexpression (Clin Cancer Res 2001;7:3977)
  • Has both pulmonary and extrapulmonary metastatic deposits; pulmonary metastatic lesions are usually high grade lesions (Sarcoma 2012;2012:345161)
  • Patients with > 5% round cell component are at higher risk of local recurrence, metastasis and tumor-related death and should be considered for adjuvant radiotherapy and possibly chemotherapy (Sarcoma 2011;2011:538085)
Micro Images

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Various percentages of round cells

Comparison of low grade and high grade tumors

Molecular / Cytogenetics Description