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Soft Tissue Tumors
Nevus lipomatosus superficialis
Author: Nat Pernick, M.D., PathologyOutlines.com, Inc.
Reviewer: David Lucas, M.D., University of Michigan Health Systems (January 2009)
Revised: 26 June 2009, last major update June 2009
Definition
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● Nodules of mature fat tissue within dermis
● Either solitary or multiple
Terminology
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● Also called nevus lipomatosus cutaneous superficialis and dermolipoma
● Not a WHO diagnosis
● First described in 1921 by Hoffman and Zurhelle
● Considered to be a developmental anomaly or hamartoma
Epidemiology
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● Uncommon
● At birth or by age 20 years
Clinical
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● Buttocks or upper thighs
● Either solitary (more common) or multiple type of Hoffmann-Zurhelle (Tunis Med 2006;84:800)
Case reports
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● 7 year old girl with congenital lesion of calf (J Postgrad Med 2005;51:47)
● 12 year old girl with neck lesion (Indian J Dermatol Venereol Leprol 2006;72:66)
● 35 year old woman with thigh lesion (Archives of Iranian Medicine)
● 45 year old man with lower back lesion (Indian Journal of Dermatology, Venereology and Leprology 1994;60(1))
Treatment and prognosis
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● Excision; does not recur
Clinical images
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Lower back
Gross description
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● Soft yellow papules
Gross images
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Cerebriform lesion of back (fig 1)
Brown-red nodules Cerebriform lesion of lower back
Micro description
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● Mature adipocytes in dermis
● No encapsulation or connection with subcutaneous fat
● No distinct epidermal changes
Micro images
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Dermal adipose tissue is Ectopic fat in mid to lower dermis
continuous with underlying subcutis
Adipose tissue in upper dermis (fig 2) Various images
End of Soft Tissue Tumors > Nevus lipomatosus superficialis
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