Soft tissue
Adipose tissue
Pleomorphic lipoma

Author: Vijay Shankar, M.D.

Revised: 30 January 2018, last major update August 2012

Copyright: (c) 2002-2018,, Inc.

PubMed Search: Pleomorphic lipoma [title]

See also: pleomorphic lipoma / spindle cell lipoma - general, spindle cell lipoma

Cite this page: Shankar, V. Pleomorphic lipoma. website. Accessed March 25th, 2018.
Definition / general
  • Mature adipocytes, dense collagen and floret giant cells in subcutaneous tissue of neck, back or shoulder
  • Usually dermal or beneath mucous membranes
  • Rare - incidence is only 10% that of spindle cell lipoma
  • Excision, only rarely recurs
Microscopic (histologic) description
  • Circumscribed tumor with adipocytes that are variable in size at low power
  • Prominent floret giant cells (hyperchromatic, multinucleated, wreath like nuclei) and small round hyperchromatic cells
  • May have spindle cells similar to spindle cell lipoma
  • No / rare lipoblasts, no prominent vascularity
Microscopic (histologic) images

Images hosted on PathOut servers:

Numerous pleomorphic and floret cells

Images hosted on other servers:

Various images

Cytology description
Positive stains
Negative stains
Differential diagnosis