Soft tissue
Adipose tissue
Sclerosing poorly differentiated liposarcoma




Topic Completed: 1 August 2012

Revised: 21 March 2019

Copyright: 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Sclerosing poorly differentiated liposarcoma
Page views in 2018: 667
Page views in 2019 to date: 325
Cite this page: Shankar V. Sclerosing poorly differentiated liposarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/softtissueadiposesclerosinglipo.html. Accessed May 20th, 2019.
Definition / general
  • Dense stromal sclerosing tumor with scattered atypical pleomorphic cells with lipoblastic features
  • Not a WHO diagnosis
Epidemiology
  • Single study to date (Histopathology 2008;52:283)
  • Mean age 63 years, range 39 - 90 years, no gender preference
  • Either de novo or recurrence of previously resected liposarcoma
  • May represent a morphological variant of poorly differentiated liposarcoma
  • May be end stage pathway for various liposarcomas
  • Aggressive behavior
Microscopic (histologic) description
  • Dense stromal sclerosis with scattered atypical pleomorphic cells with lipoblastic features
Molecular / cytogenetics description
  • MDM2 amplification in 4 of 7 cases, negative for CHOP translocation
Back to top