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Soft Tissue Tumors

Adipose tissue-liposarcoma

Sclerosing poorly differentiated liposarcoma


Reviewer: Vijay Shankar, M.D. (see Reviewers page)
Revised: 13 November 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Dense stromal sclerosing tumor with scattered atypical pleomorphic cells with lipoblastic features
● Not a WHO diagnosis

Epidemiology
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● Single study to date (Histopathology 2008;52:283)
● Mean age 63 years, range 39-90 years, no gender preference
● Either de novo or recurrence of previously resected liposarcoma
● May represent a morphological variant of poorly differentiated liposarcoma
● May be end stage pathway for various liposarcomas
● Aggressive behavior

Micro description
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● Dense stromal sclerosis with scattered atypical pleomorphic cells with lipoblastic features

Molecular/cytogenetics description
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● MDM2 amplification in 4 of 7 cases, negative for CHOP translocation

End of Soft Tissue Tumors > Adipose tissue-liposarcoma > Sclerosing poorly differentiated liposarcoma


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