Soft tissue
Adipose tissue
Sclerosing poorly differentiated liposarcoma

Author: Vijay Shankar, M.D. (see Authors page)

Revised: 9 August 2016, last major update August 2012

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: Sclerosing poorly differentiated liposarcoma

Definition / General
  • Dense stromal sclerosing tumor with scattered atypical pleomorphic cells with lipoblastic features
  • Not a WHO diagnosis
Epidemiology
  • Single study to date (Histopathology 2008;52:283)
  • Mean age 63 years, range 39 - 90 years, no gender preference
  • Either de novo or recurrence of previously resected liposarcoma
  • May represent a morphological variant of poorly differentiated liposarcoma
  • May be end stage pathway for various liposarcomas
  • Aggressive behavior
Micro Description
  • Dense stromal sclerosis with scattered atypical pleomorphic cells with lipoblastic features
Molecular / Cytogenetics Description
  • MDM2 amplification in 4 of 7 cases, negative for CHOP translocation