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Soft Tissue Tumors
Sclerosing poorly differentiated liposarcoma
Author: Nat Pernick, M.D., PathologyOutlines.com, Inc.
Reviewer: David Lucas, M.D., University of Michigan Health Systems (January 2009)
Revised: 26 June 2009, last major update June 2009
Definition
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● Dense stromal sclerosing tumor with scattered atypical pleomorphic cells with lipoblastic features
● Not a WHO diagnosis
Epidemiology
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● Single study to date (Histopathology 2008;52:283)
● Mean age 63 years, range 39-90 years, no gender preference
● Either de novo or recurrence of previously resected liposarcoma
● May be end stage pathway for various liposarcomas
● Aggressive behavior
Micro description
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● Dense stromal sclerosis with scattered atypical pleomorphic cells with lipoblastic features
Molecular / cytogenetics
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● MDM2 amplification in 4 of 7 cases, negative for CHOP translocation
End of Soft Tissue Tumors > Sclerosing poorly differentiated liposarcoma
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