Home   Chapter Home   Jobs   Conferences   Fellowships   Books


Soft Tissue Tumors

Adipose tissue

Subconjunctival herniated orbital fat

Reviewer: Vijay Shankar, M.D. (see Reviewers page)
Revised: 11 November 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.


● Prolapse of subconjunctival intraconal orbital fat
● First described in pathology literature in 2007 (Am J Surg Pathol 2007;31:193)
● Not a WHO diagnosis

Clinical features

● Rarely causes an intraorbital mass lesion
● Mean age 66 years, 90% men
● Prolapse is usually into superotemporal quadrant or lateral canthus
● Usually due to orbital fat herniation through a dehiscence in Tenon's capsule
● Manifests as unilateral or bilateral yellowish mass
● Does not recur

Case reports

● Infant with small yellow mass in right eye (Eur J Pediatr 2010;169:1427)
● 52 year old woman with inferonasal mass (Nihon Ganka Gakkai Zasshi 2008;112:1085)

Clinical images

Various images

Micro description

● Mature fat, fibrous septa without hyperchromatic cells
● Adipocytes with intranuclear vacuoles (Lochkern cells) and floret cells (multinucleated giant cells with wreath like pattern of normal nuclei)
● Variable histiocytes, lymphocytes, plasma cells and mast cells

Positive stains

Floret cells - CD34 and vimentin
Lochkern cells - CD34, vimentin and S100

Differential diagnosis

Pleomorphic lipoma: different clinical presentation; aggregates of bland spindle cells, floret cells and wiry collagen
Well differentiated liposarcoma: different clinical presentation; enlarged hyperchromatic cells within fibrous septae

End of Soft Tissue Tumors > Adipose tissue > Subconjunctival herniated orbital fat

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at [email protected] with any questions (click here for other contact information).