Soft tissue
Adipose tissue
Spindle cell lipoma

Author: Vijay Shankar, M.D.

Revised: 30 January 2018, last major update August 2012

Copyright: (c) 2002-2018,, Inc.

PubMed Search: Spindle cell lipoma

See also: pleomorphic lipoma / spindle cell lipoma - general, pleomorphic lipoma

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Page views in 2019 to date: 7,614
Cite this page: Shankar, V. Spindle cell lipoma. website. Accessed August 24th, 2019.
Definition / general
  • Mature adipocytes, bland spindle cells with wispy eosinophilic cytoplasm in subcutaneous tissue of neck, back or shoulder (Stanford University)
Case reports
Gross images

Images hosted on PathOut servers:

Yellow tumor due to numerous adipocytes

Microscopic (histologic) description
  • Mixture of mature adipocytes and bland spindle cells (pale eosinophilic cytoplasm with uniform wavy nuclei similar to neurofibroma) in mucinous / myxoid or fibrous background with thick collagen bundles
  • Spindle cells are arranged in short fascicles with occasional nuclear palisading
  • May have hemangiopericytic or angiomatous vascular pattern (Pathol Int 2007;57:26)
  • May have minimal / no fat (Am J Dermatopathol 2007;29:437)
  • Variable mast cells and lymphocytes
  • No storiform pattern, no lipoblasts, no / rare mitotic activity
Microscopic (histologic) images

Images hosted on PathOut servers:

Adipocytes, spindle cells and ropy collagen

Pseudoangiomatous appearance

Spindle cells have inconspicuous cytoplasm and small, slender, uniform nuclei

Spindle cells and collagen with few adipocytes

Images hosted on other servers:

Spindle cell lipoma

Various images

Cytology description
  • Scattered clusters of mildly pleomorphic spindle cells mixed with mature adipocytes, mast cells and small collagen fragments (Diagn Cytopathol 2000;23:362)
Cytology images

Images hosted on other servers:

Figure 5:
Breast tumor,
H&E and CD34

Positive stains
Negative stains
Electron microscopy description
Molecular / cytogenetics description
  • Usually 16q abnormalities
Differential diagnosis
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