Soft tissue
Skeletal muscle
Rhabdomyoma
Adult type rhabdomyoma


Topic Completed: 1 November 2012

Minor changes: 13 October 2020

Copyright: 2002-2020, PathologyOutlines.com, Inc.

PubMed Search: Rhabdomyoma [title] adult

Vijay Shankar, M.D.
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Cite this page: Shankar V. Adult type rhabdomyoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/softtissueadultrhabdomyoma.html. Accessed October 24th, 2020.
Definition / general
Clinical features
  • Very rare
  • Usually head and neck, particularly oral cavity
  • Median age 60 years, 75% male (Hum Pathol 1993;24:608)
  • May be multifocal (25%)
Case reports
Treatment
  • Excision is curative, but may recur if incompletely excised
Clinical images

Contributed by Mark R. Wick, M.D.

Base of tongue, CT

Gross description
  • Median 3 cm, circumscribed, soft, tan-red-brown
  • Nodular or lobulated
Gross images

Contributed by Mark R. Wick, M.D.

Base of tongue

Microscopic (histologic) description
  • Well circumscribed, not encapsulated, sheets of large, well differentiated skeletal muscle cells
  • Cells are round or polygonal with abundant eosinophilic fibrillar or granular cytoplasm with frequent cross striations and intracytoplasmic rod-like inclusions
  • Nuclei are small, round and vesicular, may have prominent nucleoli
  • May have spider cells with vacuolated cytoplasm (cells resemble spider webs)
  • Variable glycogen and lipid
  • No mitotic activity, no atypia
Microscopic (histologic) images

AFIP images

Abundant eosinophilic and granular cytoplasm

Distinct well demarcated lobules of polygonal cells

Large closely
packed polygonal
cells up to
150 microns

Haphazardly
arranged crystalline
material resembling
sarcomeric bands

Crystalline material resembles rods



Contributed by Mark R. Wick, M.D.

Various images



Images hosted on other servers:

Large closely packed polygonal cells up to 150 microns

Abundant eosinophilic and granular cytoplasm

Actin+

Desmin+

Cytology description
  • Fragments of tumor cells, which are large, polygonal cells
  • Cytoplasm is eosinophilic and finely granular, may resemble granular cell tumor, which is S100+, muscle markers- (Diagn Cytopathol 2009;37:483)
  • Eccentrically placed nuclei
  • Cross striations and inclusions are not conspicuous (Acta Cytol 2010;54:968)
Cytology images

Images hosted on other servers:

Various images

Positive stains
Negative stains
Electron microscopy description
  • Myofilaments, Z bands, glycogen granules
Differential diagnosis
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