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See subtypes below: AnaplasticSolid

General
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Sites
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Clinical features
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Case reports
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Treatment and prognosis
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Clinical images
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Retro-orbital, courtesy of Dr. Mark R. Wick

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Multiple nodules on foot

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Progressive enlargement of skin lesions

Gross description
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Gross images
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Courtesy of Dr. Mark R. Wick

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Congenital post-auricular tumor

Micro description
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Micro images
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Tumor cells grow in nests or clusters separated by fibrous septa (AFIP)

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Solid growth (AFIP)

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Alveolar type spaces contain desquamated small, round and
poorly differentiated skeletal muscle cells; fibrovascular
stroma is lined by undifferentiated round cells and
differentiating cells with abundant eosinophilic
cytoplasm, but only rare cross striations (AFIP)

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Various images

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Solid growth with giant cells

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Desquamated multinuclear giant cells (AFIP)

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May resemble lipoblasts

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Focal rhabdoid cells

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Predominantly solid areas with only focal
alveolar pattern resembles embryonal
rhabdomyosarcoma (AFIP)

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May resemble embryonal RMS
due to small round spindled cells
with hyperchromatic nuclei and
vacuolated spider cells

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Perineal skin of infant

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Various images

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Desmin

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Myogenin



Courtesy of Dr. Mark R. Wick:

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Leg

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Orbit

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Unspecified

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Myogenin

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Nasopharynx, desmin

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Nasopharynx, PAS

Cytology images
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Figure 1


Fig. 1: Cellular exudate with reactive mesothelial cells (double arrow), lymphocytes (arrowhead), bizarre giant cells (single arrow) and mitotic figures (double arrowhead), cells have vacuolated cytoplasm (inset), tumor cells are desmin+ (3A), myogenin+ (3B), karyotype shows t(2;13) (fig 4)

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Alveolar structures

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Neoplastic cells

Positive stains
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Electron microscopy description
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Electron microscopy images
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Courtesy of Dr. Mark R. Wick

Molecular / cytogenetics description
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Molecular / cytogenetics images
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t(2;13): G-banding above
R- banding below

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t(2;13)(q35;q14) and
t(1;13)(p36;q14)

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Comparison of wild type
and fusion products
associated with t(2;13)
and t(1;13)

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FISH

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t(2;13) ISH, courtesy of Dr. Mark R. Wick

Videos
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Differential diagnosis
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Anaplastic variant

General
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Treatment and prognosis
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Micro description
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Micro images
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Foci of anaplastic cells
(nuclei are hyperchromatic and
3x larger than surrounding cells)




Solid variant

General
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Case reports
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Micro description
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Micro images
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Various images

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Primary tumor

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Desmin+, courtesy of Dr. Mark R. Wick

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Cytokeratin, desmin, myoD1, myogenin

Positive stains
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Molecular description
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Molecular images
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FISH and karyotype show t(2;13)

End of Soft Tissue > Skeletal muscle > Alveolar rhabdomyosarcoma



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